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Utilization of 3D ultrasonography for nuchal translucency measurment
Širůčková, Anna ; Harabiš, Vratislav (referee) ; Kolář, Radim (advisor)
This thesis is review of the newest methods of diagnose congenital defects of fetus in first trimester mainly Down´s syndrome. Nuchal translucency is primary marker for assessment the risk of aneuploidy. The aim of this project is to clarify the most modern techniques, three dimensional ultrasound, using for measuring of nuchal translucency. Fetal Medicine Foundation set straight guidelines for measuring, practice and audits, which are recommended. In this thesis, the focus is also on possible ways of audit by quantitative and qualitative evaluation. In the last part, I designed the study for evaluation of presented techniques. The aim is to qualify the benefits of tool Sono NT and Volume NT.
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Optimized methodology of caliper positioning for ultrasound measurement of nuchal translucence
Kolářová, Dana ; Kolář, Radim (referee) ; Provazník, Ivo (advisor)
This thesis focuses on the research of methods for first trimester screening of congenital defects of the fetus. Ultrasound markers of aneuploidy, the algorithm of the first trimester screening and brief description of chromosomal aberrations diagnosable in the first trimester of pregnancy are described in the literature search. Nuchal translucency is the most important marker of aneuploidy in the first trimester and the work also deals with the measurement methodology currently used, which was created by the Fetal Medicine Foundation (FMF). The aim is to describe the limitations of the methodology and explain inaccuracies that arise due to FMF recommendations. The biggest drawback of the methodology is the influence of parameters set on ultrasound machines before and during the actual measurement, therefore it is necessary to come with new methodology not affected by them. The new methodology is based on the knowledge of the parameter influence and is independent of parameter settings of ultrasound machines. The final part of the thesis includes a study comparing the standard derivation of measurement results in both methods.
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Markers for the prediction of preeclampsia and their relevance in the first trimester of pregnancy
Šedová, Lenka ; Kestlerová, Andrea (advisor) ; Švandová, Ivana (referee)
Preelampsia is a clinical syndrome found uniquely in a pregnant patient with an incidence 2 - 8 % of pregnancies worldwide. It is defined as the new onset of hypertension and proteinuria after 20 weeks of gestation, resolving with delivery or soon thereafter. Its worst consequences are eclampsia with tonic and clonic seizures and possibly coma. Also pulmonary edema, CNS hemorrhage, anaemia, hepatorenal failure, circulation failure and other complications can occur. In its most severe form, it affects nearly every organ. Preeclampsia remains a major cause of premature delivery and both maternal and neonatal mortality and morbidity. The origin and the cause of the disease remain unknown and therefore the medical treatment focuses only on clinical manifestations. Timely prediction of preeclampsia would enable accurate therapeutic treatment and a decrease of the threat to maternal and fetal health. In this study, the most important predictive biomarkers of PE and their relevance in the first trimester of gestation are presented. Furthermore, a first trimester screening with the best prediction rates is described. Powered by TCPDF (www.tcpdf.org)
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Markers for the prediction of preeclampsia and their relevance in the first trimester of pregnancy
Šedová, Lenka ; Kestlerová, Andrea (advisor) ; Švandová, Ivana (referee)
Preelampsia is a clinical syndrome found uniquely in a pregnant patient with an incidence 2 - 8 % of pregnancies worldwide. It is defined as the new onset of hypertension and proteinuria after 20 weeks of gestation, resolving with delivery or soon thereafter. Its worst consequences are eclampsia with tonic and clonic seizures and possibly coma. Also pulmonary edema, CNS hemorrhage, anaemia, hepatorenal failure, circulation failure and other complications can occur. In its most severe form, it affects nearly every organ. Preeclampsia remains a major cause of premature delivery and both maternal and neonatal mortality and morbidity. The origin and the cause of the disease remain unknown and therefore the medical treatment focuses only on clinical manifestations. Timely prediction of preeclampsia would enable accurate therapeutic treatment and a decrease of the threat to maternal and fetal health. In this study, the most important predictive biomarkers of PE and their relevance in the first trimester of gestation are presented. Furthermore, a first trimester screening with the best prediction rates is described. Powered by TCPDF (www.tcpdf.org)
|
|
|
Utilization of 3D ultrasonography for nuchal translucency measurment
Širůčková, Anna ; Harabiš, Vratislav (referee) ; Kolář, Radim (advisor)
This thesis is review of the newest methods of diagnose congenital defects of fetus in first trimester mainly Down´s syndrome. Nuchal translucency is primary marker for assessment the risk of aneuploidy. The aim of this project is to clarify the most modern techniques, three dimensional ultrasound, using for measuring of nuchal translucency. Fetal Medicine Foundation set straight guidelines for measuring, practice and audits, which are recommended. In this thesis, the focus is also on possible ways of audit by quantitative and qualitative evaluation. In the last part, I designed the study for evaluation of presented techniques. The aim is to qualify the benefits of tool Sono NT and Volume NT.
|
|
|
Optimized methodology of caliper positioning for ultrasound measurement of nuchal translucence
Kolářová, Dana ; Kolář, Radim (referee) ; Provazník, Ivo (advisor)
This thesis focuses on the research of methods for first trimester screening of congenital defects of the fetus. Ultrasound markers of aneuploidy, the algorithm of the first trimester screening and brief description of chromosomal aberrations diagnosable in the first trimester of pregnancy are described in the literature search. Nuchal translucency is the most important marker of aneuploidy in the first trimester and the work also deals with the measurement methodology currently used, which was created by the Fetal Medicine Foundation (FMF). The aim is to describe the limitations of the methodology and explain inaccuracies that arise due to FMF recommendations. The biggest drawback of the methodology is the influence of parameters set on ultrasound machines before and during the actual measurement, therefore it is necessary to come with new methodology not affected by them. The new methodology is based on the knowledge of the parameter influence and is independent of parameter settings of ultrasound machines. The final part of the thesis includes a study comparing the standard derivation of measurement results in both methods.
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